Major Depressive Disorder in Adults: Symptoms, Diagnosis, and Inpatient Treatment

Clinical depression is a lot different than feeling down or occasionally sad. Major depressive disorder fundamentally alters how your brain functions, affecting everything from your mood and thinking to your physical health. 

The weight of depression can make even the easiest of tasks feel impossible, draining the meaning from activities that once brought you great joy. Plus, MDD affects over 20 million American adults each year, making it one of the most common mental health conditions.
1 

Yet, despite this prevalence, the condition is often misunderstood, sometimes dismissed as a potential weakness or something you simply need to “get over.” However, learning more about the difference between normal sadness and clinical depression can help people access much-needed treatment. 

Depression is treatable, so if you suspect that you or someone you love has it, a mental health professional can talk to you about your options. This page can also help you better understand the major depressive disorder adults can experience by exploring: 
  • The definition and major symptoms of major depressive disorder in adults
  • What constitutes a major depressive episode
  • How MDD differs from other depressive and mood-based disorders
  • How to access chronic depression management for ongoing struggles
  • When psychiatric residential care is needed for specialized care
woman laying on the sofa with her hands to her face looking worried due to major depressive disorder in adults

The Basics of Major Depressive Disorder

Major depressive disorder in adults involves persistent, pervasive periods of low mood and additional symptoms that significantly impair your ability to function in everyday life.2 

Clinical
depression isn’t a character flaw, nor is it a sign of personal weakness. You can’t overcome it through the power of positive thinking. It involves real changes in functioning and potential neurotransmitter imbalances, leading to several symptoms that define the disorder. 

A clinical depression diagnosis requires symptoms lasting for at least two weeks and causing major distress or alteration in your functioning. It must be a change from your previous functioning and cannot be better explained by something such as bereavement.
1 The next section explores the diagnostic criteria in more detail. 

DSM-5 Diagnostic Criteria

The Diagnostic and Statistical Manual of Mental Disorders requires at least five of the following nine symptoms to be present during the same two-week period in order to be diagnosed. Additionally, at least one symptom must involve having a depressed mood or a loss of interest in things that were once enjoyed.1 
  • Depressed mood most of the day, every day
    : Feeling sad, empty, hopeless, or tearful almost every day. 
  • Losing interest or pleasure in activities: A notably diminished interest or pleasure taken in activities, including hobbies, socialization, sex, or things you previously enjoyed. 
  • Changes in weight and appetite: Weight loss when not restricting calories, weight gain, or decreased/increased appetite nearly every day, along with changes in body weight of more than 5% within one month. 
  • Ongoing sleep disturbances: Experiencing either insomnia or hypersomnia (sleeping excessively).
  • Changes in psychomotor activity: Observable agitation (such as restlessness, pacing, or an inability to sit still) or slowing down. 
  • Feeling fatigued: Feeling exhausted even after getting enough rest, with simple tasks requiring enormous effort. 
  • Feelings of worthlessness or guilt: Excessive, inappropriate guilt about past actions, feeling like a burden to others, or ongoing beliefs about being “flawed” or “inadequate.” 
  • Cognitive difficulties: A diminished ability to think, concentrate, or make decisions nearly every day. 
  • Thoughts of suicide: Ongoing thoughts about dying or suicidal ideation, suicide attempts, or planning to end your life. 

Major Depressive Episode vs. Major Depressive Disorder

A major depressive episode is a period of time that meets the symptom criteria described above. It involves at least two weeks of depressed mood or loss of interest, plus additional symptoms causing you impairment.
3 

In other words, an episode represents a period of time with a clear beginning and (hopefully) end. 

Major depressive disorder, meanwhile, is diagnosed when you experience one or more major depressive episodes without a history of manic or hypomanic episodes (which would indicate
bipolar disorder instead). 

This difference can matter for treatment planning. A single major depressive episode might resolve with more short-term interventions, while recurrent MDD can often require long-term or lifelong treatment to prevent relapse. 

Chronic depression
management for people who experience multiple episodes focuses on treating both their acute symptoms and preventing future episodes with ongoing therapy and medication management. 
Find out about our free depression assessment & admissions process

We accept most major insurance providers and can check your coverage levels for you.

If we are not an appropriate provider for care, we will assist in finding a care provider that can help. 

Major Depressive Disorder vs. Other Mood Disorders

Mood disorder treatment can look quite different depending on what specific condition you’re experiencing. While MDD is the most common depressive-based disorder, many other conditions can also involve depressive symptoms that have different prognoses and courses of treatment. We discuss some of these other conditions in the following sections.

Persistent Depressive Disorder (Dysthymia)

Persistent depressive disorder involves having a depressed mood lasting at least two years, with symptoms that are usually less severe than a major depressive episode.4 For instance, you might be able to function all right while depressed, but never feel truly “well.” 

In other words, MDD involves distinct episodes with clear beginnings and ends, whereas persistent depressive disorder becomes your baseline over time. However, some people are diagnosed with both PDD and depressive episodes. 

Premenstrual Dysphoric Disorder

PMDD entails experiencing severe mood symptoms during the week or two before menstruation that tend to improve within days of your period beginning.5 Premenstrual dysphoric disorder shares many symptoms with major depression, including irritability, feeling sluggish, and potential appetite changes. 

If your depressive symptoms only occur around your period and resolve once menstruation begins, PMDD might help to explain the pattern. However, some people have both conditions, which can make navigating depressive symptoms more challenging. 

Seasonal Affective Disorder

Seasonal affective disorder means that you have major depressive episodes that follow seasonal patterns, usually during the fall and winter months (summer SAD exists, but is less common).6 

The seasonal patterns distinguish SAD from MDD, though both involve the primary symptoms of clinical depression. 

Other Disorders and Conditions

As mentioned previously, both bipolar I and bipolar II disorders involve major depressive episodes that look the same as MDD, but they also occur alongside manic or hypomanic episodes. 

An adjustment disorder can also involve emotional or behavioral symptoms in response to identifiable challenges such as job loss, divorce, serious illness, or other major life changes. These symptoms typically don’t meet the level of a major depressive episode. 

Additionally, normal
grief following the death of a loved one can involve symptoms that resemble depression. However, grief is a normal part of the loss process, typically becoming better on its own over time and occurring in waves as you adjust. 

Complex grief can persist for beyond a year after the loss, which indicates its own treatment considerations.
7 

Does Commercial Health Insurance Cover Treatment for Major Depressive Disorder Near Me?

Health insurance companies generally provide insurance coverage for major depressive disorder treatment programs.  Your health policy can include coverage for some, if not most, of the costs associated with MDD treatment. This can include inpatient and outpatient treatment, based on the severity of your symptoms.

Health insurance policies may have limitations or exclusions regarding your use of out-of-network medical treatment centers. Your plan may also be subject to out-of-pocket expenses in the form of copayments, deductibles, and premiums. Complete the AMFM insurance verification form to learn about the details of your coverage.

Accessing Care for Chronic Clinical Depression

Chronic depression management often requires sustained treatment rather than brief interventions, with care coordinated across providers and different levels of care depending on symptom severity and your life circumstances. The following information discusses the different levels of care involved in treatment.

Outpatient Mental Health Services

Depression therapy options in outpatient settings include individual therapy with licensed mental health providers, using evidence-based approaches like cognitive-behavioral therapy and psychodynamic therapy to address thought patterns and functioning issues. 

Psychiatric medication management can also occur via appointments with prescribers to assess the benefits of antidepressant medications. 

Many people benefit from combined treatment; therapy addressing psychological and behavioral aspects of depression, alongside medication for correcting neurochemical imbalances. Research has shown that combined treatment typically provides the best outcomes. 

Intensive Outpatient Programs and Partial Hospitalization Programs

When weekly therapy isn’t enough for your needs but you don’t require 24/7 care, IOP and PHP programs can provide a useful middle ground. 

Intensive outpatient programs (IOPs) involve multiple therapy sessions weekly, including group therapy and skills training alongside individual therapy and prescriber appointments, while you continue living at home. 

Partial hospitalization programs (PHPs) offer full-day treatment services several days a week, with evenings spent at home. 

The added daily structure to these programs can provide you with more intensive interventions while also allowing you to maintain your independence and daily connections. 

When Inpatient Treatment Becomes Necessary

Inpatient depression programs provide you with the highest level of care for situations that exceed what outpatient care can safely manage. 

Psychiatric residential care may be beneficial if you’re finding functioning in nearly every domain of daily life a challenge. It may also be necessary if there are any concerns around self-harm or thoughts of suicide. 

Long-term treatment for depression in a residential setting can also be beneficial for chronic or treatment-resistant depression that hasn’t responded well to other therapy attempts. 

Depression crisis stabilization can be more effective when you’re removed from chaotic or unstable home situations and away from any potential triggers. It gives you a safe place to work on building new skills and stability needed to return to regular life with better coping mechanisms and effective medication plans. 

Find Depression Treatment Programs

A Mission For Michael (AMFM) provides treatment for adults experiencing various conditions. Depression support is a phone call away – call 866-478-4383 to learn about our current treatment options.

See our residences in Southern California’s Orange County & San Diego County.

Take a look at our homes on the east side of the Metro area in Washington County.

View our facilities in Fairfax County, VA within the DC metro area.

Depression Treatment Programs at AMFM

Depression might have convinced you that nothing can help, that you’ve tried everything, and this is just how life is going to be. 

A Mission For Michael helps adults with severe, chronic, or treatment-resistant depression find the support they need to recover, combining evidence-based care and psychiatric expertise in a welcoming environment. 

We treat depression alongside several other mental health conditions, and always with compassion and care. Let us show you how we can help – contact us today to get started. 

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Frequently Asked Questions About Major Depressive Disorder and Inpatient Treatment

If you have any remaining concerns or questions about the major depressive disorder adults can experience, the following responses to FAQs may help. 

How Do I Know if My Depression Is Severe Enough for Inpatient Treatment?

Your depression might be severe enough to warrant residential care if you’re struggling with suicidal thoughts (or actively planning to harm yourself). Other indicators can include psychotic features, an inability to function in day-to-day life, or not seeing the results you need from other treatment episodes. 

AMFM can help you decide what level of care is best with a full assessment of your needs and circumstances, along with assistance in understanding your insurance benefits. 

What Actually Happens During Inpatient Depression Treatment?

Inpatient depression programs allow you to attend individual and group therapy sessions and participate in therapeutic activities. Days typically follow structured schedules, along with allowing you downtime to reflect. 

The length of your stay can vary, and most programs help you to step down your care to a lower level. This way, you can be assisted in consolidating your gains and continue receiving supportive services in the long term. 

  1. National Institute of Mental Health. (2023, July). Major Depression. National Institute of Mental Health. https://www.nimh.nih.gov/health/statistics/major-depression
  2. World Health Organization. (2025, August 29). Depressive disorder (depression). https://www.who.int/news-room/fact-sheets/detail/depression
  3. ScienceDirect. (n.d.). Major depressive episode. In Medicine and Dentistry. Retrieved November 17, 2025, from https://www.sciencedirect.com/topics/medicine-and-dentistry/major-depressive-episode
  4. National Institute of Mental Health. (n.d.). Persistent Depressive Disorder (Dysthymic Disorder). Www.nimh.nih.gov. https://www.nimh.nih.gov/health/statistics/persistent-depressive-disorder-dysthymic-disorder
  5. Johns Hopkins Medicine. (2019). Premenstrual Dysphoric Disorder (PMDD). https://www.hopkinsmedicine.org/health/conditions-and-diseases/premenstrual-dysphoric-disorder-pmdd
  6. National Institute of Mental Health. (2023). Seasonal Affective Disorder. Www.nimh.nih.gov. https://www.nimh.nih.gov/health/publications/seasonal-affective-disorder
  7. Szuhany, K. L., Malgaroli, M., Miron, C. D., & Simon, N. M. (2021). Prolonged Grief disorder: Course, diagnosis, assessment, and Treatment. Focus, 19(2), 161–172. https://doi.org/10.1176/appi.focus.20200052
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