Causes of Bipolar Disorder in Adults: Genetic, Biological, and Environmental Factors

If you’ve ever found yourself riding an emotional rollercoaster of intense highs and lows, know that you’re not alone. Bipolar disorder affects roughly 37 million adults worldwide, yet still remains an often misunderstood condition.1 For people living with this disorder, its associated unpredictable mood and energy swings can feel confusing and frustrating. 

Understanding why bipolar disorder develops can be an important step toward recovery, so what actually causes it? While there’s currently no known single cause, research has identified several key risk factors for developing bipolar disorder, including genetics, brain chemistry, and environment. 

Whether you’ve been diagnosed with bipolar disorder, suspect you may have it, or are just curious why it develops, this article can help you better understand the causes. On this page, we’ll explore:
  • What bipolar disorder is
  • Genetic, biological, and environmental causes of bipolar disorder
  • Mental health triggers
  • Early signs of bipolar disorder
  • Where to find professional support
Man with head in hands looking distressed due to causes of bipolar disorder in adults

Understanding Bipolar Disorder

Life naturally comes with highs and lows: it’s all part of being human. But bipolar disorder isn’t a fleeting mood swing triggered by changing circumstances – it’s a complex and more intense emotional shift. 

Bipolar Disorder Explained

Bipolar disorder is a serious mental health condition that causes intense energy shifts and mood swings between mania (“ups”) and depression (“downs”).2 This means someone may have periods in which they feel impulsive, energized, and extremely elated or irritable (manic episodes) and also severe periods of sadness, hopelessness, or emotional numbness (depressive episodes).3 

You may have heard bipolar disorder previously referred to as “manic depression” or “manic-depressive disorder.” However, bipolar disorder is the clinically correct term for this condition as it reflects symptoms more accurately and reduces the stigma associated with the older terms.

Bipolar disorder doesn’t describe just one condition; there are actually three separate conditions on the bipolar spectrum, which are:
6 
  • Bipolar I:
    Experiencing depressive episodes lasting at least two weeks and manic episodes that either last at least one week or are so severe that you need to attend a hospital for care. Mixed moods are also possible. 
  • Bipolar II: Having depressive and hypomanic episodes (less severe than manic episodes), typically spending more time in depressive moods. 
  • Cyclothymia: Recurrent hypomanic and depressive symptoms that either don’t last long enough or aren’t intense enough to be classed as hypomanic or depressive episodes.

Impact of Bipolar Disorder

More than 3.3 million American adults are diagnosed with bipolar disorder, with many experiencing life-disrupting symptoms.4,5 The first signs of this condition often appear during adolescence or early adulthood, although a person may not be “officially” diagnosed until years later.4 Unfortunately, bipolar disorder doesn’t get better on its own. The extreme mood and energy changes can affect your ability to work, have healthy relationships, function in daily life, and increase the risk of suicidal thoughts.6

The good news is that bipolar disorder can be treated effectively with a combination of medication, therapy, and lifestyle changes, allowing you to lead a fulfilling and more balanced life. 

Causes of Bipolar Disorder

The exact cause of bipolar disorder hasn’t been pinpointed yet, despite the abundance of adult bipolar disorder information available. However, research suggests several factors may contribute to developing the condition. The potential bipolar triggers in adults include genetic, neurochemical, and environmental elements.7

Understanding how bipolar disorder happens can help you see things more clearly and treat yourself with extra compassion and kindness. Therefore, the following sections explore the risk factors associated with both bipolar disorder and bipolar mood episodes triggers.
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Understanding the Genetic Risk Bipolar Disorder Carries

Although no single specific gene is currently linked to bipolar disorder, research shows it tends to run in families.4 Here’s what we know so far:8-11
  • Over two-thirds of people with bipolar disorder have at least one close relative who also has the condition or has major depression.
  • When one parent has bipolar disorder, there’s up to a 30% chance of their child developing it. However, when both parents have bipolar disorder, the risk goes up to 75% 
  • Studies of identical twins suggest that if one twin has bipolar disorder, there is a 40-70% chance that the other will also have it 
  • First-degree relatives – parents, siblings, or children – of a person with bipolar disorder have five times the chance of developing it than a person in the general population
  • Recent research has found 36 unique genes likely to be linked to bipolar disorder

Clearly, this research indicates a strong link between family history and bipolar disorder development. However, it’s important to remember that there is no guarantee that you will develop bipolar disorder if a relative has it. The causes of bipolar disorder are complex and varied, with brain chemistry and environmental triggers also playing a role. 

Biological Causes of Bipolar Disorder

People with bipolar disorder may have different brain structures and brain functions compared to those without the condition.5

Research tells us that the brain chemistry bipolar disorder exhibits may differ in terms of neurotransmitter imbalances (specifically dopamine and serotonin) and other brain signals responsible for regulating mood. Also, studies have found differences in the actual brain structure between people with and without bipolar disorder. Furthermore, there are links between the condition’s progression and a person’s immune function, oxidative stress, and impaired cellular resilience.
7,8,12,13 

But what does this really mean?

Essentially, bipolar disorder may develop due to a fundamental difference in brain structure and the chemicals involved with mood regulation. 

So having bipolar disorder isn’t your fault, and there isn’t anything you’ve done “wrong.”  Biological factors play a big part in the causes of bipolar disorder. Another risk factor for developing bipolar disorder is environmental stress, which is explored in more detail next.

The Link Between Environmental Stress and Bipolar Disorder

So, we know that bipolar disorder has strong links with family history and brain chemistry, but what else can contribute to a person developing it?

One risk factor that hasn’t yet been discussed is adverse circumstances or environmental factors. While life-altering events may not be direct causes of bipolar disorder, they can trigger symptoms in people already predisposed to this condition.
1,4

Adverse life experiences could include distressing events like:
1,9,14

Furthermore, over 60% of adults with bipolar disorder report experiencing at least one stressful life event before having a manic or depressive episode.
7 And, although unexpected stresses cannot typically be avoided due to their nature, understanding these triggers may help you prepare for potential episodes. 

As you may be able to tell, the causes of bipolar disorder are complex. However, one thing many people wonder is whether having another mental health condition makes you more likely to develop bipolar disorder. Therefore, the next section focuses on mental health risk factors. 

Mental Health Risk Factors Associated With Bipolar Disorder

Many people have more than one mental health condition at a time. In fact, up to 70% of people with bipolar disorder also meet the criteria for another psychiatric disorder, such as anxiety disorders, attention-deficit/hyperactivity disorder (ADHD), or an eating disorder.6,7 

This may be due to some of the risk factors for bipolar disorder also being common factors for developing other mental health conditions, like anxiety.9 Additionally, data shows that having co-occurring conditions can lead to more frequent and severe symptoms in bipolar disorder.7

So, although co-occurring conditions are common in people with bipolar disorder, they aren’t necessarily what triggers it. 

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Bipolar Disorder: The Facts

Although research into the causes of bipolar disorder is ongoing, real-world data can offer us valuable insights into how it shapes the lives of adults. For instance…1,7
  • Bipolar disorder is often diagnosed between the ages of 15 and 24 years and 45 and 54 years
  • More than 70% of people experience symptoms before the age of 25 years
  • 37 million people live with bipolar disorder worldwide
  • Bipolar disorder is one of the top ten leading causes of disability globally
  • Women and men are equally affected by the condition
  • People with bipolar disorder are more likely to smoke, drink alcohol, have a physical health condition, and experience difficulties accessing health care
  • People diagnosed with bipolar disorder often live 13 years less than people without the condition
  • There is a greater risk of suicide for people with bipolar disorder (approximately 14 times that of the general population)

There’s no question that bipolar disorder is a serious mental health condition that can detrimentally affect daily life and functioning. While understanding mood disorder causes can reduce stigma and encourage compassion, recognizing the symptoms of bipolar disorder is crucial for accessing the treatment needed to manage it. 

With this in mind, the following section covers the signs of bipolar disorder to watch for so that early intervention can be provided. 

Early Signs of Bipolar Disorder

Bipolar disorder symptoms can vary from person to person. For instance, you may experience manic episodes, depressed episodes, or “mixed” periods when you have signs of both mania and depression. 

Episodes often last for a week or more, and symptoms may look like:
6

Manic episodes:

  • Feeling extremely elated or irritable
  • Having much more energy than usual
  • Talking quickly about different topics
  • Racing thoughts
  • More interest in pleasurable activities
  • Not needing much sleep
  • Feeling unusually powerful, talented, or important

Depressive episodes:

  • Feeling very down or sad
  • Experiencing very low energy levels compared to usual
  • Problems sleeping
  • Having trouble concentrating, focusing, or making decisions
  • Forgetfulness
  • Talking slowly
  • Feeling worthless or hopeless

Regardless of your risk factors for developing bipolar disorder, if the above symptoms sound familiar, they may indicate this condition. Remember that bipolar disorder can be very effectively treated and managed with the right support. 

Treatment Options

Bipolar disorder treatment often involves a combination of approaches, including:
1
  • Medications:
    Mood stabilizers and antipsychotics can be used to manage manic episodes, while antidepressants may be used to ease symptoms during periods of depression 
  • Therapy: Talking therapies such as cognitive behavioral therapy (CBT) can reduce depressive symptoms
  • Psychoeducation: Family psychoeducation can help families understand and better support their loved one 
  • Support groups: Peer support groups allow people to share their experiences and learn new coping skills from others who face similar challenges
  • Lifestyle changes: Leading a healthy lifestyle that incorporates regular sleep, exercise, a balanced diet, and stress management can benefit people with bipolar disorder 

Find Bipolar Disorder Treatment Programs

A Mission For Michael (AMFM) provides treatment for adults experiencing various conditions. Bipolar Disorder support is a phone call away – call 866-478-4383 to learn about our current treatment options.

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View our facilities in Fairfax County, VA within the DC metro area.

Find Residential Bipolar Support for Adults With AMFM

Understanding the causes of bipolar disorder can be empowering and encourage people to seek early support. If you recognize some of the signs of bipolar disorder within yourself, know that effective treatment and support are available. 

Here at AMFM, we provide a safe, structured environment designed to help you manage your moods and focus on long-term recovery from bipolar disorder. With 24/7 support, personalized treatment plans, compassionate care, and evidence-based approaches, our residential programs in California, Virginia, and Washington are here to support you when you are ready. 

Reach out to us today to take the next step toward recovery and a more stable future.

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  1. World Health Organization: WHO. (2025, September 8). Bipolar disorder. https://www.who.int/news-room/fact-sheets/detail/bipolar-disorder
  2. American Psychological Association (APA). (2024, November 15). Bipolar Disorder.  Dictionary of Psychology. https://dictionary.apa.org/bipolar-disorder
  3. National Institute of Mental Health (NIMH). (2024). Bipolar disorder. https://www.nimh.nih.gov/health/topics/bipolar-disorder
  4. Mental Health America. (2025, October 14). Bipolar Disorder. https://mhanational.org/conditions/bipolar-disorder/
  5. National Institute of Mental Health (NIMH) (n.d.). Bipolar disorder. Retrived November 5, 2025, from https://www.nimh.nih.gov/health/statistics/bipolar-disorder
  6. NIMH. (2025). Bipolar disorder. https://www.nimh.nih.gov/health/publications/bipolar-disorder
  7. Jain, A., & Mitra, P. (2023, February 20). Bipolar disorder. StatPearls – NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK558998/
  8. Depression and Bipolar Support Alliance. (2019, July 12). Bipolar Disorder Statistics.  https://www.dbsalliance.org/education/bipolar-disorder/bipolar-disorder-statistics/#:~:text=Who%20is%20Affected%20by%20Bipolar,ethnic%20groups%20and%20social%20classes
  9. Rowland, T. A., & Marwaha, S. (2018). Epidemiology and risk factors for bipolar disorder. Therapeutic Advances in Psychopharmacology, 8(9), 251–269. https://doi.org/10.1177/2045125318769235
  10. O’Connell, K. S., Koromina, M., Van Der Veen, T., Boltz, T., David, F. S., Yang, J. M. K., Lin, K., Wang, X., Coleman, J. R. I., Mitchell, B. L., McGrouther, C. C., Rangan, A. V., Lind, P. A., Koch, E., Harder, A., Parker, N., Bendl, J., Adorjan, K., Agerbo, E., Kittel-Schneider, S. (2025). Genomics yields biological and phenotypic insights into bipolar disorder. Nature, 639(8056), 968–975. https://doi.org/10.1038/s41586-024-08468-9
  11. National Institute for Health and Care Excellence (NICE). (2025). Bipolar disorder: What causes it? https://cks.nice.org.uk/topics/bipolar-disorder/background-information/causes/
  12. Owens, N. (2025, July 9). What causes bipolar disorder? WebMD. https://www.webmd.com/bipolar-disorder/bipolar-disorder-causes
  13. Scaini, G., Valvassori, S. S., Diaz, A. P., Lima, C. N., Benevenuto, D., Fries, G. R., & Quevedo, J. (2020). Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings. Brazilian Journal of Psychiatry, 42(5), 536–551. https://doi.org/10.1590/1516-4446-2019-0732
  14. Aldinger, F., Schulze, T. G., Aldinger, F., & Schulze, T. G. (2016). Environmental factors, life events, and trauma in the course of bipolar disorder. Psychiatry and Clinical Neurosciences, 71(1), 6–17. https://doi.org/10.1111/pcn.12433
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