Major Depressive Disorder: Causes, Symptoms & Treatment Options

Table of Contents

Key Takeaways

  • Major Depressive Disorder (MDD) is persistent sadness and loss of interest in daily activities.
  • Symptoms of MDD are emotional, physical, and behavioral changes.
  • Genetic, biological, environmental, and psychological factors can all contribute to MDD.
  • Treatment options include medication, therapies like CBT and TMS, holistic practices, and lifestyle changes.
  • A Mission for Michael (AMFM) helps adults with MDD through personalized and compassionate treatment plans that integrate evidence-based therapies like CBT and holistic practices like music therapy – all delivered in a serene facility. 

What is Major Depressive Disorder (MDD)?

Major Depressive Disorder (MDD) – often called clinical depression – is a mood disorder that’s characterized by persistent feelings of sadness or a lack of interest in external stimuli. It’s more intense and lasts longer than the typical sadness everyone experiences from time to time. 

Impact on Daily Life

People with MDD may struggle to get out of bed in the morning, lose interest in activities they once enjoyed, and have difficulty concentrating or making decisions. These challenges can affect work performance, relationships, and overall quality of life.

An illustration showing a man having sleep disturbances.
It’s not uncommon for individuals with MDD to experience changes in appetite or weight, sleep disturbances, and chronic pain. These physical symptoms can further worsen the emotional distress associated with MDD. 

Prevalence & Demographics

MDD is a common disorder – affecting people of all ages, races, and socioeconomic backgrounds. The World Health Organization stated that depression is a leading cause of disability worldwide. 

While MDD often first appears during the late teens to mid-20s, it can occur at any age. Women are also more likely than men to experience MDD – although the reasons for this are not fully understood.

Causes of MDD

MDD isn’t usually the result of a single event or factor but rather a combination of genetic, biological, environmental, and psychological factors: 

  • Genetic Factors: Genetics can increase the risk of MDD – especially if there is a family history of depression. Twin studies show that identical twins are more likely to both have MDD than fraternal twins.
  • Biological Influences: Changes in brain chemistry and structure, neurotransmitter imbalances, and hormonal shifts, such as during puberty or menopause, contribute to MDD. Chronic illness and medication can also impact brain function, leading to depression.
  • Environmental Triggers: Stressful life events like loss of a loved one, divorce, or financial issues can trigger or worsen MDD. Living in high-stress environments or experiencing trauma also raises the risk of developing depression.
  • Psychological Contributions: Personality traits such as low self-esteem, pessimism, and self-criticism can increase susceptibility to MDD. Having a history of mental health issues like anxiety also heighten the likelihood of depression.

Identifying Symptoms of MDD

MDD symptoms generally fall into three categories: emotional, physical, and behavioral:

  • Emotional Symptoms: MDD causes persistent feelings of sadness or emptiness that don’t go away. It leads to a loss of interest in activities once enjoyed, like hobbies or socializing. Individuals with MDD may feel irritable or frustrated over minor issues and experience overwhelming feelings of worthlessness or excessive guilt – often about things that wouldn’t normally cause concern.
  • Physical Symptoms: MDD affects physical health with changes in sleep patterns, such as insomnia or oversleeping – and appetite changes, leading to weight loss or gain. Fatigue and low energy make even simple tasks feel draining. 

An Illustration showing a man having a headache.
Some people may also experience unexplained aches, pains, headaches, or digestive issues that don’t improve with typical treatment.
  • Behavioral Changes: MDD can lead to withdrawal from social activities and isolation from friends or family, affecting relationships. People may struggle with completing daily tasks at work or school, resulting in poor performance. In some cases, individuals may have thoughts of death or suicide, which require immediate intervention and support.

Diagnosis Process

Professional Assessment

The first step in diagnosing MDD is a professional assessment. 

A healthcare provider – such as a psychiatrist or psychologist – will conduct a thorough interview using questionnaires or standardized tests to understand the individual’s symptoms, duration, and severity. 

They’ll also ask about any family history of mental health disorders and any previous episodes of depression.

MDD Diagnostic Criteria

To diagnose MDD, healthcare providers use specific criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 

According to the DSM-5, a person must experience at least five of the nine specific symptoms – including either depressed mood or loss of interest – for a minimum of two weeks.

  • Depressed mood most of the day, nearly every day, as indicated by subjective report (e.g., feeling sad, empty, or hopeless) or observation by others (e.g., appearing tearful). In children and adolescents, this can be an irritable mood.
  • Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day.
  • Significant weight loss when not dieting or weight gain (e.g., a change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day. In children, consider failure to make expected weight gain.
  • Insomnia or hypersomnia nearly every day.
  • Psychomotor agitation or retardation nearly every day (observable by others).
  • Fatigue or loss of energy nearly every day.
  • Feelings of worthlessness or excessive or inappropriate guilt nearly every day.
  • Diminished ability to think or concentrate, or indecisiveness, nearly every day.
  • Recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt.

Treatment Options Explained

Medication

Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), are commonly prescribed to help balance brain chemicals that affect mood. 

These medications may take several weeks to show their full effects. They must be taken as prescribed and not discontinued without consulting a healthcare provider.

Therapies

There are many evidence-based therapies that can be used to manage MDD: 

  • Cognitive-Behavioral Therapy (CBT): As one of the most effective and researched treatments for depression, CBT helps identify and challenge negative thoughts that impact feelings and behavior – teaching ways to replace them with healthier thought patterns. 
  • Transcranial Magnetic Stimulation (TMS): TMS is a non-invasive treatment for treatment-resistant depression. It uses magnetic stimulation on brain areas to regulate mood – it’s considered when therapy and medications haven’t provided relief.
  • Eye Movement Desensitization and Reprocessing (EMDR): EMDR helps those with depression caused traumatic events. It uses guided eye movements to reprocess memories and change emotional responses – improving emotional healing and recovery.

Holistic Practices

Holistic practices aren’t for replacing conventional treatments – they provide valuable support instead.

One popular alternative practice is mindfulness meditation – it’s about focusing on the present moment and accepting it without judgment. Studies show that mindfulness helps reduce MDD symptoms by promoting relaxation and lowering stress.

Another option is acupuncture, an ancient Chinese practice that inserts thin needles into specific points on the body to promote energy flow and balance. Research suggests acupuncture may reduce depression symptoms by stimulating the body’s natural healing processes.

Lifestyle Changes

Positive lifestyle changes – such as getting regular physical activity, having a regular sleep routine, and eating healthily – can help boost mood and improve overall mental health.

Compassionate Care for Major Depressive Disorder at AMFM

MDD can feel like an insurmountable weight, but with the right support, recovery is possible. At AMFM, we provide specialized treatment for MDD. 

We integrate evidence-based therapies like CBT, DBT, and EMDR with holistic practices like music and art therapy to address the symptoms and underlying causes.

outdoor patio at amfm mental health treatment in fallbrook, ca. Male only treatment location.
Our home-like facilities create a safe, supportive environment where you can focus on healing. With a small client-to-staff ratio, personalized care, and a multidisciplinary approach from experienced clinicians, we ensure every aspect of your recovery is addressed.

Located in many serene settings across California, Virginia, and Washington, AMFM is here to help you regain balance and hope. Take the first step—reach out today.

Frequently Asked Questions (FAQ)

How long does treatment take to show effects?

The time it takes for treatment to show effects varies depending on the individual and the treatment method. For medications, it may take several weeks to notice significant improvements in symptoms. Therapy can also take time, with progress often seen over several sessions.

Can children be diagnosed with MDD?

Yes, children and adolescents can be diagnosed with MDD. The symptoms may differ from those in adults – such as irritability, changes in school performance, or withdrawal from social activities. 

Is it possible to prevent MDD?

While it may not be possible to prevent MDD entirely, certain strategies can reduce the risk and help manage symptoms. Maintaining a healthy lifestyle, including regular exercise, a balanced diet, and sufficient sleep, can support mental health.

Building strong social connections and seeking support during stressful times can also be protective factors. Additionally, learning stress management techniques – such as mindfulness or relaxation exercises – can help individuals cope with life’s challenges more effectively.

What is a Mission for Michael?

AMFM is a mental health center that provides personalized, evidence-based treatment programs for adults with MDD – combining therapy, medication, and holistic practices in a nurturing environment.